- Journal of the Turkish Chemical Society Section A: Chemistry
- Vol: 4 Issue: 2
- EASY SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN -2-(1H)-ONES USING PHOSPHATE FERTILIZERS MAP, DAP AND TSP AS ...
EASY SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN -2-(1H)-ONES USING PHOSPHATE FERTILIZERS MAP, DAP AND TSP AS EFFICIENT CATALYSTS
Authors : Sarra Sibous, Said Boukhris, Rachida Ghailane, Nouzha Habbadi, Amina Hassikou, Abdelaziz Souizi
Pages : 481-488
Doi:10.18596/jotcsa.286900
View : 10 | Download : 7
Publication Date : 2017-03-14
Article Type : Research
Abstract :A simple, efficient and green procedure has been developed for the synthesis of dihydropyrimidinones (Products of Biginelli) using phosphate fertilizers (mono-ammonium phosphate (MAP), di-ammonium phosphate (DAP) and triple super phosphate (TSP)) as catalyst. The one-step reaction involved the three compounds, which are registered aromatic aldehydes, dicarbonyl compounds and the urea/thiourea. This new method provides some advantages such as obtaining excellent yields (98%), as well as the short duration of the reaction, which may attain 2 min. These catalytic heterogeneous systems present also the advantage of being easily recycled.Keywords : Heterogeneous catalysts, MAP, DAP, TSP, 3, 4-dihydropyrimidin-2(1H)-ones