- Journal of Medicine and Palliative Care
- Vol: 4 Issue: 4
- Investigation of the synovial fluid pro-inflammatory cytokines and clinical findings in disc displac...
Investigation of the synovial fluid pro-inflammatory cytokines and clinical findings in disc displacements of TMJ
Authors : Canay Yilmaz Asan, Şeyma Bayindir, Ahmet Emin Demirbaş, Didem Barlak Keti, Nükhet Kütük
Pages : 345-349
Doi:10.47582/jompac.1333161
View : 35 | Download : 44
Publication Date : 2023-08-30
Article Type : Research Article
Abstract :Aims: Temporomandibular disorders (TMD) are common musculoskeletal disease that affects the soft tissues and bone structures of the temporomandibular joint (TMJ). Inflammatory mediators play a critical role in the etiology of TMD by affecting various molecular mechanisms. This study aims to investigate the effect of pro-inflammatory cytokines on TMJ internal derangements and evaluate the relationship between clinical features. Methods: Patients who underwent arthrocentesis because of TMD were included in this study. Patients were divided into 2 groups according to anterior disc displacement with reduction (Group 1) and without reduction ( Group 2). Clinical findings before and after the arthrocentesis were evaluated retrospectively. Synovial fluid TNF-α, IL-1β, and IL-6 levels were analyzed with the ELISA method. Results: A total of 28 patients were included, with 15 patients in Group 1 and 13 patients in Group 2. All patients were female with an average age of 30.75±14.9. The average pre-operative pain score was 6.6±1.95 in all patients. After the arthrocentesis, the average pain score was 2.0 ( 1.0 - 2.5) and the difference was significant (p<0.001). Group 1 have a higher maximum mouth opening (MMO) than Group 2 preoperatively and the difference was statistically significant (p=0.013). The difference in synovial fluid cytokine levels was not statistically significant between groups. There was no statistically significant correlation between cytokines and clinical findings. Conclusion: Arthrocentesis is beneficial for reducing joint pain in patients with TMJ internal derangements. Pro-inflammatory cytokine levels are similar in TMJs with disc displacement with and without reduction.Keywords : Temporomandibular Eklem, TME, enflamatuar, sitokin, sinovyal sıvı