- Journal of New Results in Science
- Cilt: 12 Sayı: 3
- Synthesis of (E)-7-arylidene-5-(hydroxy(aryl)methyl)bicyclo[3.2.0] heptan-6-one derivatives as anti-...
Synthesis of (E)-7-arylidene-5-(hydroxy(aryl)methyl)bicyclo[3.2.0] heptan-6-one derivatives as anti-cancer agents
Authors : Mustafa Ceylan, Bahar Zorlu, Ayşe Şahin Yağlioğlu, Nuray Akdoğan Üremiş, Meliha Burcu Gürdere, Meryem Keçeci Sarikaya, Yakup Budak
Pages : 149-156
Doi:10.54187/jnrs.1366848
View : 81 | Download : 104
Publication Date : 2023-12-31
Article Type : Research
Abstract :7,7-Dichlorobicyclo [3.2.0]heptan-6-one was prepared by adding dichloroketene to cyclopentene. Reduction of 7,7-dichlorobicyclo[3.2.0]heptan-6-one with Zn in acetic acid afforded the bicyclo[3.2.0]heptan-6-one. (E)-7-Arylidene-5-(hydroxy(aryl)methyl)bicyclo [3.2.0]heptan-6-ones were synthesized by addition of related benzaldehydes to bicyclo[3.2.0]heptan-6-one. The anti-proliferative activities of synthesized compounds were elucidated against rat brain tumor (C6) and human cervical carcinoma cells (HeLa) cell lines. The most active compound was chloro derivative against C6 cell lines with IC50 = 2.45 μM value (5-FU, IC50 = 14.82 μM). Moreover, the most active compound was methyl derivative against HeLa cell lines with IC50 = 26.30 μM (5-FU, IC50 = 29.30 μM).Keywords : α, β-Unsaturated ketones, Anti-proliferative activity, C6, HeLa, 5-Fu