- Journal of Immunology and Clinical Microbiology
- Vol: 8 Issue: 1
- PCR Diagnosis, Epidemiological and Clinical Data of Crimean-Congo Hemorrhagic Fever Virüs in Tokat/T...
PCR Diagnosis, Epidemiological and Clinical Data of Crimean-Congo Hemorrhagic Fever Virüs in Tokat/Türkiye
Authors : Metin Özdem?r, Yelda Da?cio?lu, Yunus Bulut
Pages : 24-31
Doi:10.58854/jicm.1257106
View : 7 | Download : 4
Publication Date : 2023-03-29
Article Type : Research
Abstract :Objectives: To contribute to case management algorithms and guidelines by evaluating the clinical symptoms, laboratory data, risk factors and mortality rates of patients admitted to health institutions with tick bite in Tokat. Methods: The virus determination was made from the blood by conventional PCR in 141 patient. Epidemiological data such as socio-demographic variables and risk factors were compared with clinical symptoms, biochemical and hematological parameters. Results: Of the patients, 83 (58.9%) were male, 84(59.6%) were positive. Five patients (5.95%) died in the PCR-positive group. Fever and tick contact history rates was found to be significantly higher in the PCR positive patients than the PCR negative group. Thrombocytopenia, leukopenia, aspartate transaminase (AST) elevation were found to be significantly higher in PCR positive patients. Despite the mean alanine transferase (ALT) was not significantly higher, the increase in the number of patients exceeding the reference range was found to be significantly higher in PCR-positive group (p<0.05). Conclusion: PCR diagnosis has an active role in the incubation and prehemorrhagic period diagnosis of cases with a history and risk factors, clinical symptoms and compatible hematological and biochemical parameters in the endemic region. The place of ALT and AST elevation in the case management algorithm should be better clarified. Mortality rates of the disease can be reduced by providing the health services quality and a well-functioning surveillance system. Efforts to increase the knowledges of people living in rural areas about the disease may be effective in controlling the disease.Keywords : PCR Teşhisi, Kırım-Kongo Kanamalı Ateşi, Epidemiyolojik ve Klinik Veriler