- Journal of Immunology and Clinical Microbiology
- Vol: 4 Issue: 4
- Do Mean Platelet Volume and Red Cell Distribution Width Predict Mortality in Patients with Acute Res...
Do Mean Platelet Volume and Red Cell Distribution Width Predict Mortality in Patients with Acute Respiratory Distress Syndrome?
Authors : Gülseren YİLMAZ, Ziya SALİHOGLU
Pages : 97-106
View : 10 | Download : 3
Publication Date : 2019-12-31
Article Type : Research
Abstract :Background: To investigate the role of mean platelet volume (MPV), red cell distribution width (RDW) and other parameters of complete blood count on predicting mortality in patients withacute respiratory distress syndrome (ARDS). Methods: Forty-six patients admitted to the intensive care unit of our institute -a tertiary center- with ARDS between April 2016 and January 2019 were retrospectively recruited in the study. Demographic and clinical data including age, gender, accompanying chronic diseases, the Acute Physiology and Chronic Health Evaluation (APACHE) scores and laboratory test results were retrospectively collected from medical records and electronic databases. The study population was divided into two groups according to the development of mortality as survivors or non-survivors. Results: Twenty-five subjects died during the in-hospital course (non-survivors) and 21 survived (survivors). APACHE II scores , MPV, RDW andneutrophil–lymphocyte ratio (NLR) were significantly higher in the non-survivors group compared to that of the survivors. Multiple logistic regression analysis revealed that MPV and RDW were independent predictors of mortality in patients with ARDS. ROC curve analysis indicated a cut-off value of 8.11 fl for MPV (sensitivity 88%, specificity86%) and 14.45 % for RDW (sensitivity 84%, specificity86 %) to predict mortality in patients with ARDS. Conclusions: MPV, as an emerging indicator of preexisting inflammation, and RDW indicating inflammation, independently predict mortality in patients with ARDS. Implementation of MPV and RDW might be useful in identifying patients who will require advanced support during admission for ARDS.Keywords : Acute respiratory distress syndrome, mean platelet volume, red blood cell distribution width