- Journal of Health Sciences and Medicine
- Vol: 6 Issue: 4
- Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimoto's thyroiditis...
Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimoto's thyroiditis: a clinical and molecular docking study
Authors : Elif Sibel Aslan, Savaş Gür
Pages : 705-712
Doi:10.32322/jhsm.1243597
View : 467 | Download : 372
Publication Date : 2023-07-30
Article Type : Research Article
Abstract :Aims: Our approach in this study is to investigate the collective effect of various parameters, including vitamin B12 (B12), vitamin D (Vit-D), folic acid, and iron deficiency, on Hashimoto\'s thyroiditis (HT) disease. This differs from existing literature that has examined these parameters individually. Methods: The study evaluated age, gender, thyroid stimulating hormone (TSH), free-T4 (FT4), free-T3 (FT3), Vit-D levels, as well as autoantibodies against thyroid peroxidase (anti-TPO) and anti-tyroglobulin iron (anti-TG) levels, ferritin, B12, and folic acid parameters in a total of 30 HT patients and 37 non-HT patients. These parameters were assessed by analyzing the patients\' routine blood test results using automated analysis methods. Results: A negative correlation was found between the blood, Vit-D level and anti-TG (as the vit-D value increases, the anti-TG decreases) (r=-0.417; p=0.001; p 0.05). However, the study emphasized the critical role of vitamin D in the pathophysiology and treatment of HT. Furthermore, molecular docking simulations indicated that folic acid could potentially act as a potent inhibitor of human extracellular signal-regulated kinase (ERK2), which has been reported to play a key role in HT.Keywords : Hashimoto, otoimmun disease, Vitamin D (vit-D), anti-TPO, Ferritin, Vitamin B12