- Journal of Health Sciences and Medicine
- Vol: 5 Issue: 3
- The diagnostic value of calcium binding protein S100A8/A9 and S100A12 in acute pancreatitis
The diagnostic value of calcium binding protein S100A8/A9 and S100A12 in acute pancreatitis
Authors : Okan Bardakci, Murat Daş, Hilal Şehitoğlu, Ece Ünal Çetin, Ünzile Atalay, Uğur Küçük, Fatih Kamiş, Alpaslan Tanoğlu, Yavuz Beyazit
Pages : 844-849
Doi:10.32322/jhsm.1096501
View : 14 | Download : 3
Publication Date : 2022-05-30
Article Type : Research
Abstract :Background: S100A8/A9 and S100A12 which are the major calcium-binding proinflammatory proteins secreted by granulocytes, has been proposed to be related to distinct disease states of inflammatory origin. This study aims to explore the circulating levels of S100A8/A9 and S100A12 in acute pancreatitis (AP) and reveal their relationship with conventional inflammatory markers. Material and Method: Serum S100A8/A9 and S100A12 were determined in AP patients (male/female: 17/13) by using a specific enzyme-linked immunosorbent assay (ELISA) method at both onset and remission and in 30 healthy controls (male/female: 17/13). Results: Significantly higher S100A8/A9 and S100A12 levels were found in AP patients compared to healthy controls (p<0.001). Circulating levels of S100A8/9, S100A12 and C-reactive protein (CRP) were found to be elevated in AP patients at disease onset compared with remission. The correlation analysis demonstrated a significant association between S100A8/A9 and S100A12 (r=0.366, p=0.047). The cut-off level for S100A8/A9 for detecting AP was ≥54.4 ng/ml with a sensitivity and specificity of 96.7% and 73.3% (AUC: 0.958). The optimum cut-off level for S100A12 for detecting AP was ≥350.25 ng/ml with a sensitivity and specificity of 73.3% and 76.7% (AUC: 0.752) respectively. Conclusion: Circulating S100A8/A9 and S100A12 levels were found to be elevated in AP patients. Both of these markers might serve as an additional tool in the diagnostic workup in AP since S100A8/A9 and S100A12 were significantly correlated with CRP.Keywords : Acute pancreatitis, S100A8/A9, S100A12, CRP, inflammation