- Journal of Health Sciences and Medicine
- Vol: 4 Issue: 1
- Investigation of the contribution of concentrated growth factor (CGF) and processed lipoaspirate (PL...
Investigation of the contribution of concentrated growth factor (CGF) and processed lipoaspirate (PLA) to wound healing in diabetic rats
Authors : Ali Bolat, Yıldırım Gültekin
Pages : 33-37
Doi:10.32322/jhsm.804331
View : 7 | Download : 3
Publication Date : 2021-01-21
Article Type : Research
Abstract :ABSTRACT Aim: The aim of the study is to show the effectiveness of concentrated growth factor (CGF) and processed lipoaspirate (PLA) in wound healing in diabetic rats. Materyal and Method: A total of 30 rats were used in the study. İt was divided into 3 groups as CGF, PLA and control group. The rats were made diabetic using Sreptozotocin IP. A 5mm diameter wound was created on one of the hind legs of all rats by using a punch. CGF and PLA were applied to the lesions. Daily wound size and wound condition were recorded on days 3, 5 and 10. At the end of the study, blood samples were taken for TNF-α, TGF-β, IL-1, PDGF, FGF and VEGF measurements before the rats were sacrificed. Results: The mean wound diameters measured on the 3rd day in the study were 4.6 ± 0.06 mm in the control group, 4.1 ± 0.05 mm in the CGF group, and 4.4 ± 0.07 mm in the PLA group. The wound diameters measured on the 5th day were 3.1 ± 0.04 mm in the control group, 1.6 ± 0.05 mm in the CGF group and 2.7 ± 0.06 mm in the PLA group (P 0.05). Conclusion: In this study, it was shown that CGF application was more effective than PLA application in wound healing in diabetic rats. Keywords: CGF, PLA, diabetic rat, ulcerKeywords : CGF, PLA, diabetic rat, ulcer