- Journal of Contemporary Medicine
- Cilt: 14 Sayı: 1
- Fecal Calprotectin At The Time Of Diagnosis May Indicate The Presence Of Complications In Inflammato...
Fecal Calprotectin At The Time Of Diagnosis May Indicate The Presence Of Complications In Inflammatory Bowel Disease
Authors : Murat Erkut, Esra Özkaya, Sami Fidan, Arif Mansur Coşar
Pages : 1-8
Doi:10.16899/jcm.1362566
View : 70 | Download : 44
Publication Date : 2024-01-31
Article Type : Research
Abstract :Aim: We aimed to investigate the relationship between the presence of complications at the time of diagnosis or during follow-up and fecal calprotectin in patients with inflammatory bowel disease. Materials and Methods: Fecal calprotectin level was studied by the chromatographic lateral flow immunoassay method. Results: A total of 76 patients, 26 (34%) with Crohn\'s disease and 50 (66%) with ulcerative colitis, were included in the study. At the time of diagnosis and during follow-up, complications were observed in 17 (22%) and 20 (26%) patients, respectively. At the time of diagnosis, fecal calprotectin level was low (<50 mg/kg) in 26 (34%) patients, borderline (50-100 mg/kg) in 16 (21%) patients, and high (>100 mg/kg) in 34 (45%) patients. Hemoglobin and albumin levels were lower (p=0.013, p=0.012, respectively), and platelet count, eryrocyte sedimentation rate, and C-reactive protein levels were higher (p<0.001, p=0.004, p<0.001, respectively) in patients with high fecal calprotectin level than patients with low fecal calprotectin level. At the time of diagnosis and during follow-up, complications were higher in patients with high fecal calprotectin level than patients with low and borderline fecal calprotectin levels (p=0.001). The risk of developing complications was found to be 26 times higher at the time of diagnosis in patients with fecal calprotectin level >100 µg/g than patients with fecal calprotectin level below this value and 8 times higher during follow-up (p=0.006, p=0.015, respectively). Conclusion: The use of fecal calprotectin level together with tests showing acute inflammation in inflammatory bowel disease may predict the development of complications.Keywords : Fekal kalprotektin, inflamatuvar bağırsak hastalığı, komplikasyonlar, akut faz reaktanları