- Journal of Contemporary Medicine
- Cilt: 13 Sayı: 5
- Evaluation of Vitamin B12, Folic Acid, Ferritin and Vitamin D Levels in Obsessive Compulsive Disorde...
Evaluation of Vitamin B12, Folic Acid, Ferritin and Vitamin D Levels in Obsessive Compulsive Disorder
Authors : Okan Imre, Rahim Kocabaş
Pages : 994-998
Doi:10.16899/jcm.1335202
View : 36 | Download : 37
Publication Date : 2023-09-30
Article Type : Research
Abstract :Aims: Obsessive compulsive disorder (OCD) is a heterogeneous disorder characterized by obsessions and compulsions. Despite the studies, etiopathogenesis is not fully understood. Pharmacological and psychosocial interventions in OCD may be insufficient due to limited knowledge of etiopathogenesis. Therefore, it is important to find inexpensive and easily determined biochemical parameters related to etiopathogenesis. In this study, the relationship between OCD and vitamin B12 (VitB12), folic acid (FA), vitamin D (VitD) and ferritin was investigated. Material and Method: 50 patients with OCD (12 female, 38 male) and 50 healthy controls (HC) (13 female, 37 male) were included in this retrospective study. Serum VitB12, FA, ferritin and 25-OH VitD levels of both groups were compared. Results: VitB12 (p <0.001), FA (p =0.004) and 25-(OH)VitD (p =0.001) serum levels were significantly lower in the OCD group than in the HC group. There was no significant difference between the two groups in terms of ferritin values. Conclusion: Our study shows that serum VitB12, FA and VitD deficiency can contribute to etiopathogenesis in OCD patients. This study may lead to research to find new pathways related to etiopathogenesis. For this, prospective studies with large participation are needed, including the post-treatment period.Keywords : Obsesyon, B12 vitamini, folik asit, ferritin ve D vitamini