- Journal of Contemporary Medicine
- Vol: 13 Issue: 3
- Do Alterations In Serum Leptin, Adiponectin, Resistin, C Peptide, Il-10, Il-22 And Visfatin Levels H...
Do Alterations In Serum Leptin, Adiponectin, Resistin, C Peptide, Il-10, Il-22 And Visfatin Levels Have An Impact On Survival In Patients With Advanced Stage Gastric And Colon Cancer?
Authors : Can Özlü, Gamze Gokoz Dogu, Ayşegül Kargi, Hakan Akça, Aydın Demiray, Burcu Yapar Taşköylü, Atike Gökçen Demiray, Serkan Değirmencioğlu, Arzu Yaren, Ahmet Ergin
Pages : 451-458
View : 48 | Download : 74
Publication Date : 2023-05-31
Article Type : Research Article
Abstract :Abstract Background/Aims: Pathogenesis of cancer cachexia is not fully understood yet; however, adipocytokines are considered necessary in this context. In this study, leptin, adiponectin, resistin, c-peptid, IL-10, IL-22, visfatin which are considered to be among markers of cancer cachexia were assessed. Methods: Fifty-three patients (34 male, 19 female) and 20 healthy people as a control group were included into this study. Blood samples were stored in deep freeze at -70 ºC and all of the samples were analyzed with appropriate biochemistry kit. Along with demographic data and laboratory tests results serum adiponectin, leptin, IL-10, IL-22, C peptide, resistin, visfatin levels were measured in 3 different time period both in patient and control group. Statistical data were evaluated by SPSS v22. Results: There was no statistically significant relationship between adipocytokine levels and progression-free survival. Higher resistin and IL-10 levels were associated with shorter overall survival (p=0.035, p=0.14, respectively). There was no significant relationship between other cytokines and overall survival. Multivariate analysis has shown that higher serum Ca 19.9 levels (OR 0.226, P=0.005), lower BMI (OR 5.726, p= 0.007), higher serum IL-10 levels (OR 0.329, p= 0.042) were factors showing an impact on progression-free survival; lower serum albumin levels (OR 0.282, p=0.013), higher serum LDH levels (OR 0,338, p=0.012), low BMI at diagnosis (OR 5.19, P<0.0005) were factors having an impact on overall survival. Conclusions: Our study detected an association between resistin, adipocytokine, and IL10 level and overall survival.Keywords : Cancer cachexia, Cancer cachexia, Adipocytokines, Adipocytokines, Adiponectin, Gastric cancer, Colon cancer