- Journal of Contemporary Medicine
- Vol: 13 Issue: 2
- Comparison of Pre-Operative and Post-Operative Thiol-Disulfide Levels in Acute Abdomen Patients
Comparison of Pre-Operative and Post-Operative Thiol-Disulfide Levels in Acute Abdomen Patients
Authors : Altan Aydin, Hakan Buluş, Alper Yavuz, Mehmet Berksun Tutan, Murat Alişik, Özcan Erel
Pages : 247-250
Doi:10.16899/jcm.1244258
View : 10 | Download : 6
Publication Date : 2023-03-22
Article Type : Research
Abstract :Aim: To evaluate role of thiol and disulfide homeostasis, a novel marker of oxidative stress, in the follow-up acute abdomen. Material and Method: This prospective study included 107 patients (62 men and 45 women) with a diagnosis of acute abdomen (AA). In all patients, age, gender and cause of acute abdomen were recorded. In addition, native thiol (-SH), total thiol (tSH) and disulfide (-S-S-) levels at baseline, admission and on postoperative day 3 were prospectively recorded and -SS-/-SH, -S-S-/tH and -SH/tSH ratios were calculated. Results: When the causes of acute abdomen were assessed, it was seen that 72 patients (67.29%) underwent surgery due to appendicitis while 5 patients (4.67%) due to lower GIS perforation, 7 patients (6.54%) due to perforated peptic ulcer, 5 patients (4.67%) due to sigmoid volvulus, 4 patients (3.74%) due to strangulated hernia and 14 patients (13.08%) due to miscellaneous reasons. When thiol and disulfide levels were assessed as a single parameter, mean thiol level was 316.71±78.16 (327.5) at preoperative period and 264.00±72.85 (278.30) at postoperative period. The mean thiol level was significantly decreased at postoperative period (p<0.001). The disulfide//thiol ratio was 5.17±1.56 (5.16) at preoperative period and 5.36±2.45 (5.28) at postoperative period, indicating no significant difference (p=0.563). Conclusions: In this study, it was found that monitoring these parameters resulting from thiol oxidation are valuable at both preoperative and postoperative period in patients with acute abdomen. Further studies are needed to optimize use of oxidative stress marker together with other established marker.Keywords : akut karın, disülfid, laboratuvar çalışması, tiyol