- İstanbul Journal of Pharmacy
- Vol: 51 Issue: 1
- Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin
Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin
Authors : Sinem ŞAHİN, Burcu MESUT, M. Ezgi DURGUN, Esher ÖZÇELİK, Yıldız ÖZSOY
Pages : 26-34
View : 13 | Download : 2
Publication Date : 2021-04-30
Article Type : Research
Abstract :Background and Aims: The study aimed to design a Fixed-dose tablet formulation of Metformine and Repaglinide. Methods: Wet granulation method was used to prepare tablet formulations. Characterization studies and dissolution studies were performed. Results: A stable formulation was developed according to the requirements of the pharmacopoeia criteria. This new formulsation dissolution results showed that Repaglinide and Metformin HCl dissolved more than 85% from film tablets at 15 minutes. Conclusion: Thus, an alternative product to the market product was developed.Keywords : Fixed-Dose Tablet, Metformin, Repaglinide