- İstanbul Journal of Pharmacy
- Vol: 49 Issue: 2
- A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines
A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines
Authors : Çağla Begüm Apaydin, Zafer Cesur
Pages : 61-63
View : 25 | Download : 6
Publication Date : 2019-08-01
Article Type : Research
Abstract :DOI : 10.26650/IstanbulJPharm.2019.19002 This report is about an unexpected formation of N,N’-bis(substituted phenoxyacetyl) hydrazine derivatives. The reaction between N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide with sulfanyl acids to obtain 4-thiazolidinones s, gave an unexpected product, N,N’-bis(phenoxyacetyl)hydrazine, with high purity instead of the expected cyclocondensation product. When repeating the reaction with p-toluenesulfonic acid under the same conditions, the reaction resulted in the same compound. This indicates that two molecules of N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide were involved in the reaction. The reaction can be applied as a different and new procedure for the synthesis of several N,N’-bis(substituted phenoxyacetyl)hydrazine derivatives. Cite this article as: Apaydın ÇB, Cesur Z (2019). A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines. Istanbul J Pharm 49 (2): 61-63.Keywords : Diacylhydrazines, sulfanyl acid, reaction mechanism