- International Journal of Secondary Metabolite
- Vol: 6 Issue: 1
- Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and t...
Microwave-assisted synthesis of N-benzylidene-4-fluoroaniline and N-benzylidene-4-Nitroaniline and their inhibitory activities on hCA isoenzymes
Authors : Hülya Çelik, Aynur Babagil
Pages : 38-48
Doi:10.21448/ijsm.479108
View : 5 | Download : 1
Publication Date : 2019-03-16
Article Type : Research
Abstract :In this study, N-benzylidene-4-fluoroaniline (3a), N-benzylidene-4-nitroaniline (3b) as a result of condensation of benzaldehyde (1) and 4-fluoroaniline (2a), 4-nitroaniline (2b) using a microwave method was synthesized. The structures of the synthesized compounds were characterized by Fouirer Transform İnfrared Spektrofotometre (FTIR spectroscopy), Nuclear Magnetic Resonance (NMR spectroscopy) and elemental analysis methods. The prepared compounds were tested for their inhibitory effects on carbonic anhydrase isoenzymes (hCA-I and hCA-II). The results showed that the synthesized compounds 3a and 3b had a strong inhibitory effect on hCA-I and hCA-II enzymes activity in vitro. By testing these compounds in other CA isoenzymes, more effective CA inhibitors can be formed. Thus, new therapeutic applications can be made for enzyme activators in the near future.Keywords : Schiff, Microwave, Fluoroaniline, Nitroaniline, Inhibitor