- International Journal of Secondary Metabolite
- Vol: 4 Issue: 3, Special Issue: 2 Special Issue
- Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro
Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro
Authors : Ramazan ERENLER, İbrahim DEMİRTAS, Tunay KARAN, Muhammed ALTUN, Fatih GUL
Pages : 512-516
Doi:10.21448/ijsm.377767
View : 10 | Download : 1
Publication Date : 2017-12-20
Article Type : Research
Abstract :Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.Keywords : Kickxia spuria, flavone, HeLa