- International Journal of Chemistry and Technology
- Vol: 6 Issue: 2
- Polymer – flufenamic acid delivery systems for injured skin
Polymer – flufenamic acid delivery systems for injured skin
Authors : Minodora Maria Marin, Mihaela Violeta Ghica, Alpaslan Kaya, Denisa Ioana Udeanu, Madalina Albu Kaya, Cristina-elena Dinu-pîrvu, Lăcrămioara Popa, Valentina Anuța, Razvan Mihai Prisada
Pages : 114-121
Doi:10.32571/ijct.1135548
View : 8 | Download : 4
Publication Date : 2022-12-31
Article Type : Research
Abstract :Collagen, the main protein of the body, is extracted in different forms and used as reservoir for drug delivery. The aim of this work was to obtain a drug delivery system based on collagen-dextran matrices cross-linked with glutaraldehyde as support and flufenamic acid and/or microcapsules with flufenamic acid as drug. The flufenamic acid was encapsulated in polymeric microcapsules consisting in gelatin, alginate, and sodium carboxymethyl cellulose. The morphology of matrices was determined by water absorption and contact angle. The biodegradation was performed in collagenase solution. In vitroflufenamic acid release profiles were built and the kinetic mechanism was set according to different mathematical models. The pharmacological studies followed the effect of collagen formulations treatment on the healing process of Wistar rats which were induced experimental wounds. The studied matrices proved that flufenamic acid delivery can be controlled, and the healing can be completed using the designed spongious matrices.Keywords : Collagen sponges, microcapsules, flufenamic acid, kinetic release, wound healing