- International Journal of Chemistry and Technology
- Vol: 5 Issue: 1
- The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon ...
The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma
Authors : Bedriye Seda Kurşun Aktar, Ayşe Şahin Yağlioğlu, Emine Elçin Oruç-emre
Pages : 52-58
Doi:10.32571/ijct.910580
View : 15 | Download : 4
Publication Date : 2021-06-30
Article Type : Research
Abstract :The anticancer activities 3-(substituted phenyl)-1-[4-(morpholine-4-yl)phenyl]prop-2-en-1-one derivatives were investigated against PC3 (Human Prostate Carcinoma Cell) and HT29 (Human colon colorectal adenocarcinoma) cell lines. The anticancer activity tests were performed by the BrdU ELISA method. 5-Fluorouracil (5-FU) was used as standard compound. Compound 1-7 (except Compound 3) were determined to have higher anticancer activity than 5-FU aganist PC3 cancer cells. IC50 values of the Compounds 1-7 against PC3 cancer cells were 2.53±0.02 µM; 4.40±0.03 µM; 4.36±0.03 µM; 1.76±0.02 µM; 1.78±0.03 µM; 2.31±0.03 µM, respectively.Keywords : HT29, PC3, Chalcone, 5-Fluorouracil, Fluor atom, anticancer activity