- International Journal of Chemistry and Technology
- Vol: 1 Issue: 1
- Determination of spectrophotometric protonation constant of cholinesterase inhibitors
Determination of spectrophotometric protonation constant of cholinesterase inhibitors
Authors : Yaşar Doğan DALDAL, Ebru ÇUBUK DEMİRALAY, Güleren ALSANCAK
Pages : 7-13
Doi:10.32571/ijct.335934
View : 14 | Download : 4
Publication Date : 2017-10-12
Article Type : Research
Abstract :T he protonation constant (pK a ) of rivastigmine, galantamine and donepezil which are cholinesterase inhibitors used in cure of Alzheimer's disease in acetonitrile-water binary mixtures were determined at 25 o C in ionic strength by spectrophotometric method. Spectra of the drugs were recorded with 1 nm resolution over the 200 to 400 nm interval. Data assessment was carried out with the STAR software program to calculate molar absorbances and stability constants of the compounds studied. A queous protonation constant of these compounds were calculated from determined through linear relationship between the mole fraction of acetonitrile and the pK a v alues and the Yasuda-Shedlovsky equality. The pK a values of inhibitors at 25°C were converted to values at 37°C, without extra estimation. The predicted and calculated pK a values were compared with literature values.Keywords : Cholinesterase Inhibitors, Protonation Constant, UV-VIS Spectrophotometry, Solute Descriptors