- Hittite Journal of Science and Engineering
- Vol: 9 Issue: 4
- Design, Synthesis and Characterization of 1,2-Phenylenediamine Functionalized Poly (Maleic Anhydride...
Design, Synthesis and Characterization of 1,2-Phenylenediamine Functionalized Poly (Maleic Anhydride-alt-Vinyl Acetate) as a Potential New Bioactive Formulation
Authors : Gülderen Karakuş
Pages : 305-311
Doi:10.17350/HJSE19030000284
View : 7 | Download : 2
Publication Date : 2022-12-31
Article Type : Research
Abstract :This study includes the design, synthesis and characterization of 1,2-phenylenediamine (o-PDA) functionalized maleic anhydride (MA)-vinyl acetate (VA) copolymer-based conjugate to develop a new formulation. The 1,2-phenylenediamine molecule is a fluorescent dye that allows designing new chemotherapeutic polymeric molecules. Poly(maleic anhydride-alt-vinyl acetate) [Poly(MA-alt-VA)] was obtained via charge transfer complex (CTC) radical polymerization presence of methyl ethyl ketone (MEK), utilizing benzoyl peroxide (BPO) free-radical initiator at 80 °C, as a potential functional polymeric carrier. Structural characterization of the surface functionalized poly(MA-alt-VA)/1,2-PDA conjugate was performed by Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) and Nuclear Magnetic Resonance (1H-NMR). Spectroscopic methods and water solubility results confirmed that the conjugation took place successfully after the ring opening reaction by the amidation mechanism.Keywords : poli(MA-alt-VA), Surface modification, 1, 2-phenylenediamine, ATR-FTIR, 1H-NMR