- Hacettepe Journal of Biology and Chemistry
- Vol: 51 Issue: 2
- EVALUATION AND COMPARISON OF THE ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF SOME AMINO ACID METHYL ES...
EVALUATION AND COMPARISON OF THE ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF SOME AMINO ACID METHYL ESTERS
Authors : Tuğçe Deniz Karaca, Hüseyin Balci, Arzu Aysan
Pages : 133-140
Doi:10.15671/hjbc.1183477
View : 12 | Download : 4
Publication Date : 2023-04-01
Article Type : Research
Abstract :In this study, the antibacterial and cytotoxic activities of some amino acid methyl esters (L-methionine, L-phenylalanine, L-histidine, L-lysine, L-tryptophan, and L-tyrosine) were investigated. The effect of amino acid methyl ester compounds on antibacterial performance was determinated against Gram-negative and Gram-positive bacteria. The effect of amino acid esters on cell viability was investigated against cancerous and non-cancerous cell lines using the MTS assay. The results showed the substances had low antimicrobial effect on both Gram-negative and Gram-positive bacteria. In addition, it was found that the studied substances did not have a toxic effect on cell growth in non-cancerous cells. For this reason, it is thought that the results obtained will contribute to research on new synthesizable compounds based on amino acid esters and studies on drug development.Keywords : Amino Acid Esters, Antibacterial Activity, Antiproliferative Activity, Cytotoxicity