- Hacettepe Journal of Biology and Chemistry
- Vol: 50 Issue: 2
- Synthesis of New Pyrazole Compounds via Diketonic Michael Adducts
Synthesis of New Pyrazole Compounds via Diketonic Michael Adducts
Authors : Seda Çinar, Aslı Eren
Pages : 157-162
Doi:10.15671/hjbc.954044
View : 7 | Download : 4
Publication Date : 2022-02-28
Article Type : Research
Abstract :Pyrazole ring containing heterocyclic molecules have been known to show biological activity. In this work, by realizing the cyclization reactions of diketonic Michael adducts, synthesis of new pyrazole compounds was accomplished. Diketonic Michael adducts were prepared in low-good yields by the addition reactions of acetylacetone to nitrovinyl arene compounds in the presence of piperidine. Pyrazole compounds were obtained in high yields via the cyclization reactions of these molecules. Structures of all the addition and the cyclization products were clarified by using 1H NMR, 13C NMR and HRMS techniques.Keywords : Nitrovinyl arene, Michael addition, cyclization, pyrazole