- Hacettepe Journal of Biology and Chemistry
- Vol: 48 Issue: 1
- Synthesis, characterization and antimicrobial studies of new chiral amide-Schiff base derivatives
Synthesis, characterization and antimicrobial studies of new chiral amide-Schiff base derivatives
Authors : Seda Yüksekdanaci, Demet Astley, Ihsan Yaşa
Pages : 33-39
Doi:10.15671/hjbc.520248
View : 7 | Download : 3
Publication Date : 2020-04-17
Article Type : Research
Abstract :In this study, new chiral Schiff bases ( 3 - 9 ) obtained from the reaction of chiral amide derivatives with different substituted aromatic aldehyde were synthesized. All synthesized compounds structures were characterized by FTIR, 1 H-NMR, 13 C-NMR and elemental analysis. All of the new synthesized compounds were tested in vitro against Staphylococcus aureus, Bacillus cereus , Escherichia coli , Salmonella thyphimirium , Klebsiella pneumoniae , Enterococcus faecalis , Pseudomonas aeruginosa , Candida albicans for their antibacterial and antifungal activities. All compounds have shown moderate to good antibacterial activity against Gram-positive and Gram-negative bacteria. Among the compounds tested compound 7 showed most potent inhibitory action against test organisms.Keywords : amino acid, amide, schiff base, antimicrobial