- Hacettepe Journal of Biology and Chemistry
- Vol: 47 Issue: 2
- Novel Methyl 4,6-O-Benzylidene--D-Glucopyranoside Derivatives: Synthesis, Structural Characterizati...
Novel Methyl 4,6-O-Benzylidene--D-Glucopyranoside Derivatives: Synthesis, Structural Characterization and Evaluation of Antibacterial Activities
Authors : Mirajul Islam, Arifuzzaman Arifuzzaman, Monjur Rahman, Mohammad Atiar Rahman, Sarkar Mohammad Abe Kawsar Kawsar
Pages : 153-164
Doi:10.15671/hjbc.622038
View : 7 | Download : 4
Publication Date : 2019-09-18
Article Type : Research
Abstract :Carbohydrates are the most abundant and the most diverse biopolymers in nature. Due to the importance of carbohydrates it is necessary to develop a new method for the synthesis of carbohydrate based drugs of the current global situation for health and disease. In this present work we demonstrate the synthesis of methyl 4,6-O-benzylidene--Dglucopyranoside derivatives by direct acylation method. The structures of the newly prepared compounds have been characterized and elucidated using various physico-chemical and spectroscopic methods including elemental analysis, melting point determination, infrared and proton NMR spectroscopy. A number of acyl derivatives were prepared in order to obtain a series of newer components for antibacterial screening experiments. These acylated derivatives were evaluated for in vitro antibacterial screening studies against four human pathogenic bacteria by disc diffusion method.Keywords : Synthesis, benzylidene, acylation, structure, pathogens