- Hacettepe Journal of Biology and Chemistry
- Vol: 46 Issue: 2
- Development of MIP-based QCM Sensors for Determination of Hyaluronic Acid (HA)
Development of MIP-based QCM Sensors for Determination of Hyaluronic Acid (HA)
Authors : Sibel Emir-diltemiz
Pages : 273-283
View : 10 | Download : 3
Publication Date : 2018-06-03
Article Type : Research
Abstract :I n this study, quartz crystal microbalance (QCM) based recognition systems have been developed for the determination of hyaluronic acid (HA). For this purpose, firstly; N-methacryloyl-l-tyrosine (MAT), MAT-DGlucuronic acid (MAT-D-GA) and MAT-Cu(II)-D-Glucuronic acid (MAT-Cu(II)-D-GA) pre-organized monomers have been synthesized, and characterized. Then, D-glucuronic acid active sites of HA biomacromolecule have been imprinted on QCM sensor surface to create HA selective binding sites. In the last step, the binding interactions, usabilities in recognition and determination of prepared sensors have been investigated.Keywords : Hyaluronic acid, MIP-QCM, mıp, quartz crystal microbalance, molecularly ımprinted polymers