- Gazi University Journal of Science
- Vol: 25 Issue: 3
- A Fourier Transform Infrared Spectrophotometry Method Used For Oseltamivir Determination in Pharmace...
A Fourier Transform Infrared Spectrophotometry Method Used For Oseltamivir Determination in Pharmaceutical Formulations
Authors : Y Aboul-enein, Andrei Bunaciu, Sultana Nita, Serban Fleschin, Zeynep Aydogmus
Pages : 631-634
View : 11 | Download : 4
Publication Date : 2012-07-19
Article Type : Other
Abstract :A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of oseltamivir phosphate (OP) in pharmaceutical formulations. Conventional KBr-spectra were compared for best determination of the active substance in pharmaceutical preparations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression ( PCR +) methods, were used in data processing. Key words : FT-IR analysis, oseltamivir, chemometric methods, pharmaceutical analysis.Keywords : FT-IR analysis, oseltamivir, chemometric methods, pharmaceutical analysis.