- European Journal of Research in Dentistry
- Cilt: 7 Sayı: 3
- Evaluation of 4% Mangosteen (MG) Gel as a Local Drug Delivery in adjunct to Scaling and Root planing...
Evaluation of 4% Mangosteen (MG) Gel as a Local Drug Delivery in adjunct to Scaling and Root planing on Clinical Parameters and GCF MMP-9 levels in Chronic Periodontitis Patients - A Split Mouth Randomized Controlled Trial
Authors : Manjiri Kulkarni, Gayathri Gunjiganur Vemanaradhya, Triveni Mg
Pages : 130-138
Doi:10.29228/erd.57
View : 51 | Download : 57
Publication Date : 2023-12-26
Article Type : Research
Abstract :Objective: The current study was conducted to assess the efficacy of 4% Mangosteen (MG) gel in adjunct to Scaling and root planing (SRP) on clinical parameters and Gingival Crevicular Fluid (GCF) matrix metalloproteinase 9 (MMP-9) levels in the management of patients with chronic periodontitis. Methodology: This double blinded, randomized, placebo-controlled, split mouth, clinico-biochemical study was carried out on 13 patients (26 experimental sites) with Stage II and Grade B periodontitis. Following subgingival SRP, the 13 control sites were treated with LDD of placebo gel and the 13 test sites with 4% MG gel. Clinical parameters including plaque index (PI), gingival bleeding index (GBI), probing depth (PD) and relative attachment level (RAL) were recorded and GCF was collected from all the experimental sites for MMP-9 analysis, using Enzyme Linked Immunosorbent Assay (ELISA); at baseline and 3 months post treatment. Results: Both, control and test sites, demonstrated improvement in the clinical parameters and reduction in GCF MMP-9 levels during the study period. Test sites exhibited a statistically significant reduction (P <0.05) in PD and RAL (gain in clinical attachment level; CAL) and GCF MMP-9 levels than the control sites. All the clinical parameters showed a positive correlation with the GCF MMP-9 levels. Conclusion: Within the limitations of this study, 4% MG gel proves to be an efficacious adjunctive agent to SRP, for management of chronic periodontitis.Keywords : Garcinia mangostana, GCF, Yerel ilaç dağıtımı, MMP-9, Periodontitis, Ölçeklendirme ve kök planlaması