- Eskisehir Medical Journal
- Cilt: 4 Sayı: Ek Sayı Özel Sayı
- EVALUATION OF SERUM RESOLVIN D1 AND E1 LEVELS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES
EVALUATION OF SERUM RESOLVIN D1 AND E1 LEVELS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES
Authors : Irfan Küçük, Ersin Tural, Başak Çakir Güney, Musa Salmanoğlu, Mustafa Kaplan
Pages : 212-219
View : 69 | Download : 88
Publication Date : 2023-10-16
Article Type : Research
Abstract :Introduction: Resolvin molecules have anti-inflammatory activity in inflammatory bowel diseases (IBDs). We aimed to evaluate whether serum resolvin D1 (RvD1) and resolvin E1 (RvE1) values can correlate to clinical and laboratory traits of IBDs. Methods: This case-control study included 62 patients with IBDs (32 ulcerative colitis (UC) patients, 30 Crohn’s disease (CD) patients) and 28 healthy controls. The Mayo Clinical scoring system (MCS) was used for the clinical and endoscopic features for UC, and the Crohn\'s disease activity index was used to assess the disease activity in CD patients. Human RvD1 and RvE1 kits were used for the serum enzyme-linked immunosorbent assay. Results: RvD1 concentrations were significantly lower in UC and CD patients compared to the control group [182.69 (118.24-450.80) ng/L and 342.07 (203.57-989.04) ng/L vs. 353.65 (216.14-1125.40) ng/L respectively, p=0.002]. RvD1 and RvE1 concentrations were higher in UC patients who were in the clinically remission phase than the patients in the activation phase [602.18 (176.13-1181.60) ng/L and 170.37 (113.21-216.21) ng/L, p=0.005 vs. 302.10 (122.18-527.37) ng/L and 74.17 (67.38-122.66) ng/L, p=0.004, respectively]. RvD1 values were higher in UC patients who had inactive endoscopic findings than the patients having active disease [426.11(175.94- 891.03 ng/L and 169.62(109.97-202.80) ng/L, p=0.009, respectively]. The ROC (receiver operating characteristic curve) analysis revealed RvD1 and RvE1 levels had considerable diagnostic significances for the increased MCS in UC (AUC=0.809, 95%CI: 0.630-0.988, p<0.001 vs AUC=0.814, 95%CI: 0.637-0.991, p<0.001). Conclusion: Decreased serum RvD1 values might be used as an auxiliary biomarker for the diagnosis and the activity of UC.Keywords : Ülseratif kolit, resolvin D1, biyobelirteç