- Eastern Anatolian Journal of Science
- Vol: 5 Issue: 1
- Enzyme Inhibition Studies of Antipyrine and Aminopyrine
Enzyme Inhibition Studies of Antipyrine and Aminopyrine
Authors : Nashia Stellenboom, Murat Şentürk
Pages : 1-6
View : 12 | Download : 6
Publication Date : 2019-06-27
Article Type : Research
Abstract :The study investigated the enzyme inhibition effects of antipyrine and aminopyrine against two human carbonic anhydrase isoforms (hCA I and hCA II), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The effectiveness of these compounds as possible carbonic anhydrase (CA) and cholinesterase (ChE) inhibitors is evident from the nanomolar range IC 50 and K i values obtained. The results demonstrated that aminopyrine was a more effective inhibitor compared with antipyrine. Moreover, molecular docking results obtained from the online docking server SwissDock supported the inhibition activity results.Keywords : Aminopyrine, Antipyrine, Acetylcholinesterase, Butyrylcholinesterase, Carbonic Anhydrase