- Eastern Anatolian Journal of Science
- Vol: 4 Issue: 2
- Toxic Effect of Pesticides on Aldose Reductase Enzyme.
Toxic Effect of Pesticides on Aldose Reductase Enzyme.
Authors : Veysel ÇOMAKLI, Şevki ADEM, Çağlar GÜLER
Pages : 1-5
View : 11 | Download : 4
Publication Date : 2018-11-01
Article Type : Research
Abstract :In this study, the effect of pesticides on the enzyme activity of Aldose reductase (AR) (EC 1.1.1.21), which is involved in polyol pathway and detoxification reactions, has been investigated.For this purpose, AR enzyme was purified from chicken liver and the IC 50 values were plotted as % Activity-[I] for pesticides with inhibition effect and The maximum inhibitory effect was determined at 2,4,5-T with 162μM.Keywords : enzyme, aldose reductase, inhibition