- Balıkesir Medical Journal
- Cilt: 8 Sayı: 1
- Malignancy rates in thyroid nodules classified as benign according to the nodule size threshold of 4...
Malignancy rates in thyroid nodules classified as benign according to the nodule size threshold of 4 cm
Authors : Yunushan Furkan Aydoğdu, Emre Gülçek, Çağrı Büyükkasap, Kürşat Dikmen
Pages : 26-34
Doi:10.33716/bmedj.1424770
View : 68 | Download : 95
Publication Date : 2024-04-30
Article Type : Research
Abstract :SUMMARY Aim: The false negative rate of fine needle aspiration biopsy (FNAB) in large thyroid nodules ranges from 7.7% to 53%. The treatment of nodules that are 4 cm or larger is controversial because of the potential for false-negative FNAB results. In order to make treatment recommendations for nodules ≥4 cm in size, we compared the results of preoperative FNAB with thyroid surgery specimens. Materials and Methods: We evaluated patients who underwent thyroid surgery and had preoperative FNAB between 2017 and 2022. Patients were divided into two groups based on nodule size (<4 cm and ≥4 cm). FNAB and specimen pathology results of both groups were compared. Results: 982 patients who underwent surgery for nodular disease were evaluated. Patients in the Bethesda 2 group (n=231) were divided into two categories based on nodule size: ≥4 cm (n=56) and <4 cm (n=175). Malignancy rates were higher in the group with tumors smaller than 4 cm. FNAB and specimen results were compared. A statistically significant difference was found between the groups (p = 0.039). Conclusion: The benign fine-needle aspiration biopsy results were consistent with the specimen results in patients with nodules that were 4 cm or larger. Thyroid surgery should not be considered as the initial treatment for nodules ≥4 cm with benign cytology.Keywords : Tiroid kanseri, Nodüler tiroid hastalığı, İnce iğne aspirasyon biyopsisi, Tiroidektomi, Yanlış negatiflik oranı