- Van Sağlık Bilimleri Dergisi
- Vol: 16 Issue: 2
- The Antibiotic Resistance Patterns of Pseudomonas Aeruginosa Strains Isolated from Microbiological S...
The Antibiotic Resistance Patterns of Pseudomonas Aeruginosa Strains Isolated from Microbiological Specimens
Authors : Duygu Kübra TUNA
Pages : 152-159
Doi:10.52976/vansaglik.1220794
View : 26 | Download : 24
Publication Date : 2023-08-30
Article Type : Research Article
Abstract :Purpose: This single-center retrospective study involving the data of human participants aimed to determine the antibiotic resistance rates of Pseudomonas aeruginosa strains isolated from samples collected by the microbiology laboratory for four years. Methods: The samples of wound, blood, tracheal aspirate, abscess, vagina, cerebrospinal fluid, sputum, and urine culture isolated from 789 patients who were hospitalized in the service, intensive care and outpatient services between 2017-2021 were evaluated retrospectively for Pseudomonas species. Results: Most of culture were urine (42.7%) and sputum cultures (20.4%). Most patients applied to the service were transferred from department of chest diseases (38.6%) or from department of urology (14.3%) or palliative care unit (12.5%). The highest rates of resistances were against cefuroxime, levofloxacin and netilmicin; lowest rate of resistance was against amikacin. The resistances against aztreonam, cefepime and gentamicin significantly reduced over years (P=0.0321, 0.0038 and 0.0004, respectively) while resistances against colistin and levofloxacin considerably increased (P<0.0001 and P=0.0407, respectively). Significant decreases were observed in resistances against cefepime, ceftazidime and ciprofloxacin over years (P=0.0321, 0.0038 and 0.0004, respectively). A significant decrease in resistance of strains isolated from urine culture was only observed for cefepime over years (P=0.0003). The resistance of strains isolated from cultures of sputum, urine and respiratory secretions against levofloxacin significantly increased in 2019 while those of wound culture increased in 2020 (P=0.0145). Conclusion: Alterations in the antibiotic resistance profile were detected in patients over years due to frequently varied use of antimicrobials. To select effective treatment protocols, it is necessary to regularly determine the microorganisms and their antibiotic resistance for each hospitalKeywords : Pseudomonas aeruginosa, antibiyotik direnç, suş, kültür