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- Evaluation of Functionality and Growth Rates in Adrenal Incidentalomas: Single Center Experience
Evaluation of Functionality and Growth Rates in Adrenal Incidentalomas: Single Center Experience
Authors : Suna Avcı, Yüksel Aslı Ozturkmen, Sayid Zuhur, Gulkan Ozkan, Elif Guven, Nazan Demir, Yuksel Altuntas
Pages : 125-132
Doi:10.38175/phnx.768414
View : 343 | Download : 621
Publication Date : 2020-11-01
Article Type : Research
Abstract :Objectives: In this study, we aimed to transfer observational data on incidentaloma cases, which we encountered in our center, in terms of their radiological, histopathologic features and hormonal activities, retrospectively review the growth rates during follow-up. Material and Method: In this retrospective study 137 incidentaloma cases that met the inclusion criteria were analyzed. The medical records of all cases were analyzed statistically by recording age, sex information, hormonal examinations and imaging results, functional status of masses, histopathological findings, and information on adrenal mass diameter change during follow-up. Results: In this study, 97 (71%) patients were female and 40 (29%) were male. 99 patients (72.3%) were diagnosed with nonfunctional adenomas (NFA), 21 patients (15%) with subclinical Cushing syndrome (SCS), 9 patients (6%) with pheochromocytoma, 6 patients (4%) with hyperaldosteronism, and 2 patients (1%) with congenital adrenal hyperplasia (CAH). Patients with functional masses were significantly younger than patients with NFA (p: 0.04). Malignancy was identified in 6 patients (4%). The mean follow-up period of the patients was 20.2 ± 19.86 months. Growth in mass size was detected in 24 patients (17%). In 6 of the masses (26% of the growing masses, 4% of all the masses), growth of over 1 cm was observed. The growth rate of the masses in male patients was significantly higher than the growth rate in female patients (p: 0.031). Conclusion: The incidence of mass growth and malignancy was higher in older age and male sex. Patient’s age and sex should be bear in mind for their duration and frequency of follow-up in terms of functionality and malignant conversion.Keywords : Subklinik Cushing, Feokromasitoma, Hiperaldesteronizm, Adrenokortikal Kanser, Adrenal, İnsidentaloma