- Türkiye Çocuk Hastalıkları Dergisi
- Vol: 12 Issue: 4
- Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection
Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection
Authors : Gökçen Öz Tunçer
Pages : 280-282
Doi:10.12956/tjpd.2018.336
View : 11 | Download : 6
Publication Date : 2018-12-30
Article Type : Other
Abstract :Subcutaneous interferon beta 1a (IFN β 1a) has been shown to reduce relapse rates in patients with relapsing-remitting multiple sclerosis. We report the occurrence of severe necrotizing cutaneous reactions in a 19-year-old girl. She self injected IFN β 1a three times a week on the abdomen and both thighs. Treatment was initially well tolerated, but she described erythematous patches and local pain at the injection sites recently. The areas on the abdomen became violaceous with necrotic ulcers. Her therapy was changed to 0.5 mg fingolimod. The lesions began to improve and cicatrize after several weeks with postinflammatory hyperpigmentation. Early recognition of severe local adverse reactions and correction of the injection technique is important.Keywords : Interferon beta 1a