- Türk Doğa ve Fen Dergisi
- Vol: 12 Issue: 1
- Evaluation of the effects of ribavirin and proanthocyanidin on the clinical outcome, hematological a...
Evaluation of the effects of ribavirin and proanthocyanidin on the clinical outcome, hematological and biochemical parameters, and viral shedding in canine distemper
Authors : Şükrü Değirmençay
Pages : 125-135
Doi:10.46810/tdfd.1244940
View : 11 | Download : 2
Publication Date : 2023-03-27
Article Type : Research
Abstract :This study investigated the effects of ribavirin, proanthocyanidin, and ribavirin-proanthocyanidin in dogs naturally infected with canine distemper virus (CDV). Five groups were created, each with six dogs aged 2-6 months: one healthy control group and four patient groups. For ten days, the A group received classical treatment (CT) [fluid treatment and antibiotic], the A+R group received CT + ribavirin, the A+P group received CT + proanthocyanidin, A+R+P group received CT + ribavirin-proanthocyanidin. On days T0, T3, T7, and T10, hematological, biochemical, and clinical scores were done. These days and the fifth and tenth post-treatment days were also screened for CDV. Clinical improvement was best in the A+P, A+R, A, and A+R+P groups, respectively. The A+R group had fewer leucocytes, neutrophils, and monocytes (P<0.05). CK and CK-MB activity were significantly higher only in the A group (P<0.01), and decreased only in the A+R group as therapy progressed. CREA values were high in A+P and A+R groups (P<0.01). The lowest Ca value was in the A+R group (P<0.01). The least CDV presence was detected in the A+R group regarding viral shedding. As a result, using ribavirin or proanthocyanidin helped to lessen the severity of clinical findings, increase survival, and reduce viral shedding in dogs with CDV.Keywords : antiviral ajanlar, canine distemper virus, proantosiyanidinler, ribavirin.