SYNTHESIS OF BROMINATED QUINOLINES
Authors : Salih Ökten, Dilek Eyigün, Osman Çakmak
Pages : 8-15
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Publication Date : 2015-03-01
Article Type : Research
Abstract :In this study, bromination reactions of 1,2,3,4-tetrahydroquinoline by molecular bromine and aromatization reactions of brominated tetrahydroquinolines were reinvestigated. Optimal reaction conditions were established for 6-Bromo-1,2,3,4-tetrahydroquinoline (6-BrTHQ ) and 6,8-dibromo-1,2,3,4-tetrahydroquinoline (6,8-diBrTHQ). Improved yields and more shortened reaction times were described for the conversion of 6-BrTHQ and 6,8-diBrTHQ into 6-bromoquinoline and 6,8-dibromoquinoline.Keywords : Quinoline, tetrahydroquinoline, bromoquinoline, bromination, aromatization, DDQ