- Samsun Sağlık Bilimleri Dergisi
- Vol: 4 Issue: 2
- "Double test screening values: Are they different in IVF and spontaneous pregnancies ?"
"Double test screening values: Are they different in IVF and spontaneous pregnancies ?"
Authors : Ömür Keskin, Murat Alan, Yasemin Alan, Emrah Töz
Pages : 53-59
View : 15 | Download : 2
Publication Date : 2019-12-25
Article Type : Research
Abstract :Objective: To compare the IVF pregnancy group and spontaneous pregnancy group in terms of PAPP-A and free β-hCG Materials and methods: Among the pregnant women who applied for double test screening between September 2017 and September 2018, 42 singleton pregnancies that were pregnant as a result of IVF (in vitro fertilization) constituted our study group where 109 singleton pregnancies whose age range were matching the IVF pregnacies but were pregnant spontaneously without any assisted reproductive technologies (ART) remained in our control group. The demographic data and pregnancy outcomes of both pregnancies were similar. Findings: The mean PAPP-A (pregnancy associated plasma protein-A) was found in the control group (2.82 mlU / ml; 0.97 MoM), while in the study group 2.41 mlU / ml, 0.94 MoM). Free β-hCG (beta-human chorionic gonadotropin) values were found as 46.44, ng / ml; 1.21MoM, 53.79ng / ml in control and study groups respectively. The mean PAPP-A of the IVF pregnancy group was lower than the spontaneous pregnancy group, and the mean β-hCG was higher than the spontaneous pregnancy group, but these differences were not statistically significant (p> 0.005). Although not statistically significant; In terms of trisomy 21 we evaluated the study group as higher risk than the control group (p> 0.05). Results: The mean of PAPP-A and free β-hCG values are different in IVF and spontaneous pregnancies, and these differences in biochemical parameters affect the risk of trisomy 21.Keywords : : β-hCG, PAPP-A, IVF, spontaneous pregnancy