- Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
- Vol: 27 Issue: 2
- Investigation of Vitamins, Glutathione and Stress Biomarkers in Blood Serum of Patients with Breast ...
Investigation of Vitamins, Glutathione and Stress Biomarkers in Blood Serum of Patients with Breast Cancer
Authors : Awat Hamad AWLA IBRAIM, Dursun ÖZER, Fikret KARATAŞ, Sinan SAYDAM
Pages : 464-480
Doi:10.16984/saufenbilder.1080420
View : 10 | Download : 3
Publication Date : 2023-04-30
Article Type : Research
Abstract :Breast cancer is a genetic disease caused by the accumulation of mutations in neoplastic cells and is responsible for the highest morbidity and mortality. In this study, blood serum samples from 45 breast cancer patients and 32 healthy individuals (control group) were used. The amounts of vitamins (A, E, β-carotene, C, B1, B2, B3, B5, B6, B9 and B12), glutathione (GSH, GSSG) stress biomarkers (4-HNE, MDA) were determined by HPLC. A significant difference was found between the breast cancer patients and the control group in terms of age and body mass index (BMI) (p 0.05) with in the cancer patients. Likewise, no significant difference was observed between the serum vitamin levels of breast cancer patients who breastfeed and not breastfeed, except for vitamins B2 and B3 (p>0.05). A high level of significant difference was observed between GSH, GSSG, MDA and 4-HNE in the breast cancer patient and control groups (p<0.001). There was no significant difference found in GSSG, MDA and HNE values according to the treatment status of breast cancer patients, on the other hand, a significant difference was observed in GSH and GSH/GSSG values (p<0.05). While there was no significant difference in GSH, GSSG, MDA and 4-HNE values according to the breastfeeding status of patients, a significant difference was observed in GSH/GSSG values (p<0.05).Keywords : Breast Cancer, Vitamins, Reduced glutation, oxidised glutation, 4-hydroxy neoneal, malondealdehyde.