- Sağlık Bilimlerinde İleri Araştırmalar Dergisi
- Cilt: 6 Sayı: 2
- GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPUL...
GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION
Authors : Taghı Ahmadi Rendi, Serhat Kilinç, Selçuk Erdem, Mehmet Enes Değirmenci, Öner Şanli, Canan Kucukgergin, Semra Dogru Abbasoglu
Pages : 117-121
Doi:10.26650/JARHS2023-1273011
View : 125 | Download : 117
Publication Date : 2023-06-26
Article Type : Research
Abstract :Objective: The purpose of this investigative research was to investigatethe potential impact of a single nucleotide polymorphism (Asp148Glu) within the APE1 gene on the development of bladder cancer (BCa) andspread, and to investigate the interaction of this polymorphism withcigarette smoking in BCa patients. Materials and Methods: In a study of 256 participants, consisting of 136 healthy individuals and 120 patients with BCa, the APE1 Asp148Glu polymorphism was evaluated using "polymerase chain reaction restrictionfragment length polymorphism” analysis. Results: There were no noteworthy difference variations observed in genotype distribution between the group of individuals with BCa and the control group with regards to the APE1 gene polymorphism. Furthermore, the APE1 gene polymorphism exhibited no correlation with the clinicopathological characteristics or smoking habits of individuals with BCa. Conclusion: Based on our findings, it appears that the APE1 gene polymorphism, which plays a role in the BER pathway, does not appear to be a contributing factor in susceptibility to BCa in the Turkish population. In addition, the smoking habit may not modify BCa risk with respect to genetic variations in the APE1 gene.Keywords : APE1, polimorfizm, baz kesip çıkarma onarımı, mesane kanseri