- Sağlık Bilimlerinde İleri Araştırmalar Dergisi
- Vol: 6 Issue: 1
- COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON COR...
COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION
Authors : Derya Baykiz, Zeynep Gizem Demirtakan, Elif Ayduk Govdeli, Samim Emet, Ali Elitok
Pages : 1-9
Doi:10.26650/JARHS2023-1199242
View : 74 | Download : 62
Publication Date : 2023-02-28
Article Type : Research Article
Abstract :Objective: Coronary collateral circulation (CCC) plays a significant role in cardiovascular prognosis, and well-developed CCC improves survival. The aim of this study was to investigate whether the serum uric acid to highdensity lipoprotein cholesterol ratio (UA/HDL-C) is associated with coronary collateral development. Materials and Methods: This retrospective study enrolled 111 patients with stable coronary artery disease and at least one chronic total occlusion (CTO) at invasive coronary angiography. Blood samples were obtained from all patients before the angiography procedure. The collateral degree was determined according to the Rentrop scoring system. Patients were classified into a poor CCC group (Rentrop grades 0-1, n=47) or a good CCC group (Rentrop grades 2-3, n=64). The UA/HDL-C ratios were compared between the two groups. Results: The UA/HDL-C ratios were significantly higher in patients with poor CCC compared with the patients with good CCC (0.18 [0.06-0.49] vs 0.14 [0.05-0.31], respectively; p<0.001). In correlation analysis, the CCC was significantly negatively correlated with UA/HDL-C and UA levels (r=- 0.333, p<0.001; r=-0.502, p<0.001, respectively). According to the ROC analysis, a cut-off value of > 0.17 for the UA/HDL-C ratio predicted poor collateral development with 54.3% sensitivity and 79.3% specificity (AUC=0.711, 95% CI 0.617–0.794, p<0.001). In multivariate regression analysis, serum UA was found to be an independent predictor of poor collateral development (OR=2.818, p=0.022). Conclusion: The present study showed that although the UA/HDL-C ratio may be associated with poor collateral development, serum UA levels seem to be a better predictor of poor CCC than UA/HDL-C ratios in patients with CTO.Keywords : Kronik total oklüzyon, koroner kollateral dolaşım, ürik asit, yüksek yoğunluklu lipoprotein kolesterol