- Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi
- Vol: 6 Issue: 1
- Crystal Structure and DNA Binding Properties of A Sulfide Bridged Dimeric Schiff Base Compound
Crystal Structure and DNA Binding Properties of A Sulfide Bridged Dimeric Schiff Base Compound
Authors : Mustafa Bal, Ayşegül Köse
Pages : 818-831
Doi:10.47495/okufbed.1180912
View : 11 | Download : 7
Publication Date : 2023-03-10
Article Type : Research
Abstract :In this research, a novel 4,4\'-Diaminodiphenyl sulfide-based Schiff base compound [6,6\'-((1E,1\'E)-((thiobis (4,1-phenylene)) bis(azaneylylidene)) bis(methaneylylidene)) bis(3-(diethylamino) phenol) (A)], which is known to have good biological activity and forms the basis of anticancer drugs, was successfully synthesized. Structural characterization of the synthesized Schiff base compound was determined by FT-IR and 1H-13C NMR, spectroscopies. Also, the molecular structure of the compound was determined by a single-crystal X-ray diffraction study. The DNA binding ability of the compound was measured using UV-vis spectroscopy. Using the spectral changes, the DNA binding constant of the compound was calculated as Kb (M-1)= 6.25x105. The Kb value found suggests the existence of an intercalative interaction.Keywords : Schiff Bases, DNA binding, X-ray diffraction, Drugs, Schiff Bases, DNA binding, X-ray diffraction, Drugs