- Osmangazi Tıp Dergisi
- Vol: 45 Issue: 4
- Could the C-reactive protein/albumin Ratio Predict Mortality in Patients with Common Variable İmmuno...
Could the C-reactive protein/albumin Ratio Predict Mortality in Patients with Common Variable İmmunodeficiency?
Authors : Recep Evcen, Fatih Çölkesen, Filiz Sadi Aykan, Mehmet Kilinç, Eray Yildiz, Ümmügülsüm Yilmaz Ergün, Tuğba Önalan, Fatma Arzu Akkuş, Selim Kahraman, Mehmet Emin Gerek, Şevket Arslan
Pages : 480-486
Doi:10.20515/otd.1273621
View : 139 | Download : 137
Publication Date : 2023-07-20
Article Type : Research Article
Abstract :Common variable immunodeficiency (CVID) is the most common symptomatic immunodeficiency in adults. This study assessed the utility of using the C-reactive protein (CRP)/albumin ratio (CAR) at diagnosis to predict mortality in CVID patients. Between 2010 and 2022, hospital records and follow-up cards of patients with CVID were reviewed retrospectively. Seventy-five patients were included in the study. CRP 0–5 mg/L and albumin 3.5–5.5 g/dL were taken as references. The CAR was obtained by dividing the CRP value by the albumin value. Of the included patients, 41 (55%) were male and 34 (35%) were female. The median age was 38 (21–77) years. The mortality rate of the patients during the follow-up time was 20%. Of the patients, 41% had splenomegaly, 10.6% had malignancy, and 39% had bronchiectasis. The cut-off value of CAR to predict mortality was >2.18 (sensitivity: 88.4%, specificity: 90.1%). When the patients were classified according to the CAR, the mortality rate in the patient group with a CAR > 2.18 was statistically significantly higher than the patient group with a CAR ≤ 2.18. The CAR is a cheap, simple, and easily calculated parameter that can predict mortality in CVID patients.Keywords : Yaygın değişken immün yetmezlik, Albumin, CRP