In vitro Effects of Some Anthelminthics on the Malate Dehydrogenase and Lactate Dehydrogenase Enzyme Activities of Taenia Saginata

Authors : A. Yasemin Öztop

Pages : 365-370

View : 14 | Download : 10

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :Malate Dehydrogenase (MDH) and Lactate Dehydrogenase (LDH) activities were demonstrated in the mitochondrial and cytosolic fractions of an intestinal cestode, Taenia saginata, and then the in vitro effects of three anthelminthics, albendazole, niclosamide, and piperazine on these enzymes were investigated. The Vmax and Km values of MDH were found to be 3.00 mmol (min mg protein) -1 and 0.0166 mM respectively. In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p
Keywords : Malate Dehydrogenase, Lactate Dehydrogenase, Taenia saginata, albendazole, niclosamide, piperazine.