- Marmara Medical Journal
- Vol: 14 Issue: 2
- THE ACTIONS OF THE α-MELANOCYTE STIMULATING HORMONE (α-MSH) IN INFLAMMATORY CONDITIONS
THE ACTIONS OF THE α-MELANOCYTE STIMULATING HORMONE (α-MSH) IN INFLAMMATORY CONDITIONS
Authors : Berna Oktar, Inci Alican
Pages : 113-118
View : 22 | Download : 7
Publication Date : 2016-12-03
Article Type : Other
Abstract :Inflammation, a localized response to tissue injury, and disorders characterized by inflammation are difficult problems in clinical medicine. This difficulty stems in large part from incomplete understanding of inflammatory processes and their regulation. Recent development of the knowledge of the role of the central nervous system and neuroendocrine system in the host responses has provided a new view of the capacity of neuronal and soluble mediators in these systems to influence inflammation. One of these mediators is the endogenous neuropeptide a-MSH, which is an N-acetyl tridecapeptide derived from the cleavage of a larger precursor molecule, proopiomelanocortin (POMC). It was originally isolated and characterized from the intermediate lobe of the pituitary and it was first recognized by its effect on skin melanophores in lower vertebrates (1).Keywords :