- Journal of Contemporary Medicine
- Vol: 13 Issue: 4
- Comparison of the Effects of Clinical Outcomes on the Number of Attacks in the Course of Ulcerative ...
Comparison of the Effects of Clinical Outcomes on the Number of Attacks in the Course of Ulcerative Colitis: A Single Center Study
Authors : Hakan Şivgin, Abdurrahman Şahin, Şirin Çetin
Pages : 665-670
Doi:10.16899/jcm.1308661
View : 34 | Download : 68
Publication Date : 2023-07-31
Article Type : Research Article
Abstract :Aim: The aim of this study was to find the factors affecting the frequency of attacks of patients diagnosed with ulcerative colitis (UC). Method: In our single-center retrospective descriptive study, 40 UC patients who admitted to our hospital for follow-up from January 2021 to December 2022. The baseline demographic and clinical characteristics, laboratory values and, treatments during the disease course were compared among patients with number of attacks < 2 per year ( Group1) and number of attacks ≥2 per year ( Group 2). Results: There were 25 (male∕female:11∕14) patients in Group 1 and 15 (male∕female:7∕8) patients in Group 2. No statistically significant difference was found between the mean age, sex, age of diagnosis, duration of disease, co-morbidities and extraintestinal involvement of both groups. The median CRP values were significantly higher in the Group 2, compared to the group 1 (P = 0.04). There was statistically significant differences between groups in terms of endoscopic severe activity (12% vs, 40%; p<0.001), left-sided involvement(60% vs, 40%; p=0.02), pancolonic involvement (8% vs, 33%; p<0.001), the presence of blood in stool at the time of diagnosis (80% vs 100%; p=0.03), use of biologic agents (16% vs 40%; p< 0.001) and steroids (16% vs 33%; p=0.02). Conclusion: In UC patients who have ≥2 attacks per year presented with more advanced clinical features at onset and more severe outcomes than the number attacks < 2 per year. Blood in stool symptom and clinical parameters of severity index at the time of diagnosis are important criteria to be considered in determining the number of attacks in follow-up.Keywords : Ülseratif Kolit, Atak, Klinik Parametreler