PRIMARY EBV INFECTION AND HEMATOLOGICAL FINDINGS IN TURKISH CHILDREN: A RETROSPECTIVE, SINGLE-CENTER STUDY

Authors : Nergiz Öner, Gürses Şahin, Şule Yeşil, Ali Fettah, Fatma Nur Öz, Emre Çapkinoğlu, Azize Kilci, Şeyma Ünüvar Gök

Pages : 692-696

Doi:10.16899/jcm.1267261

View : 48 | Download : 63

Publication Date : 2023-07-31

Article Type : Research Article

Abstract :Abstract Aim: Primary infection with EBV during childhood is usually asymptomatic. Hematologic abnormalities such as hemolytic anemia, thrombocytopenia, and neutropenia are relatively common, but aplastic anemia, severe thrombocytopenia, severe neutropenia, and lymphoid malignancies are rare. In this retrospective study, we have analyzed data from children with primary EBV infection who were examined at our center over 12 years to describe the distribution, clinical features, complications, and outcome of EBV in Turkish children. Materials and Methods: Data from all children (age<18 years) with primary EBV infection who were examined in our center between 2008 and 2020 were retrospectively reviewed. Results: In total, 120 patients were included in the study. Anemia was detected in 13 (11%) children. Mild and severe neutropenia was detected in 12 (10%) and 1 (0.8%) children, respectively. Mild thrombocytopenia without bleeding complications was present in 10 (8%) children with a mean platelet count of 250x109/L ±113x109/L. Seven patients presented with acute idiopathic thrombocytopenia (lowest platelet count, 2x109/L). Large diffuse cell lymphoma developed in 0.8% (n:1) patients. Conclusion: The prognosis for infectious mononucleosis is excellent, although various acute complications may occur. However, severe complications are very rare, and most of the complications resolve spontaneously without certain therapy.
Keywords : Primer EBV enfeksiyonu, Türk çocukları, Hematolojik bulgular